Stative sentences in Japanese and the role of the nominative marker "ga" : a thesis submitted in partial fulfillment of the requirements for the degree of Master of Arts in Japanese at Massey University, Palmerston North, New Zealand

The Japanese nominative particle ga is normally associated with the marking of subjects. However, there are several constructions involving stative predicates, where it has been claimed, notably by those working within a generative framework, that a ga-marked NP can be an object and that such sentences are transitive. Such an analysis has particularly arisen in the case of sentences with more than one ga-marked NP, exhibiting so-called double ga marking. The following study makes two claims. Firstly, that one of the functions of ga in such sentences is to provide a discourse frame akin to the topic marking function of the postpositional particle wa. Secondly it argues that stative sentences associated with double ga-marking are in fact intransitive and that the ga-marked NP's that have been claimed to be objects are in fact subjects

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

Recent studies suggest a variety of factors characterize substantia nigra neurons vulnerable to Parkinson's disease, including the transcription factors pituitary homeobox 3 (Pitx3) and orthodenticle homeobox 2 (Otx2) and the trophic factor receptor deleted in colorectal cancer (DCC), but there is limited information on their expression and localization in adult humans. Pitx3, Otx2, and DCC were immunohistochemically localized in the upper brainstem of adult humans and mice and protein expression assessed using relative intensity measures and online microarray data. Pitx3 was present and highly expressed in most dopamine neurons. Surprisingly, in our elderly subjects no Otx2 immunoreactivity was detected in dopamine neurons, although Otx2 gene expression was found in younger cases. Enhanced DCC gene expression occurred in the substantia nigra, and higher amounts of DCC protein characterized vulnerable ventral nigral dopamine neurons. Our data show that, at the age when Parkinson's disease typically occurs, there are no significant differences in the expression of transcription factors in brainstem dopamine neurons, but those most vulnerable to Parkinson's disease rely more on the trophic factor receptor DCC than other brainstem dopamine neurons

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer’s and Parkinson’s disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer's disease and Parkinson's disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition

Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials

An amendment to this paper has been published and can be accessed via the original article

For a public international relations

The last few years have seen an opening up of what is considered to be the legitimate terrain of international relations (IR). This move is, for the most part, extremely welcome. Yet, the multiple theoretical and empirical openings in IR since the end of the Cold War have failed to elucidate many of the puzzles, questions and problems posed by the contemporary conjuncture. There are a number of reasons for this failure ranging from the stickiness of Cold War problem fields to IR’s continued attachment to systemic-level theories. However, this article focuses less on symptoms than on treatment and, in particular, on how generating a more “public” international relations enterprise might help to connect IR with the core theoretical, empirical and normative terrain of “actually existing” world politics. Taking its cue from recent debates in sociology about how to generate a “public sociology,” the article lays out three pathologies that a public IR enterprise should avoid and four ground rules—amounting to a manifesto of sorts—which sustain the case for a “public” international relations